UTSA cruised to a 58-24 victory over East Carolina in Week 13, with the Roadrunners controlling the game from start to finish. UTSA jumped out to an early 14-0 lead in the first quarter and never relinquished control, outscoring East Carolina 20-3 in the second quarter to build a commanding halftime advantage.

Owen McCown led the UTSA offense with 248 passing yards, while David Amador was the team's receiving leader with 75 yards. East Carolina's Parker Jenkins led the Pirates with 8 rushing yards in a losing effort.

UTSA's defense was particularly impactful, recording several momentum-shifting plays throughout the contest. A second-quarter touchdown pass from McCown to Amador and a fourth-quarter interception return for a touchdown by S. Banks Jr. highlighted the Roadrunners' dominant defensive performance.

The game saw UTSA outscore East Carolina in three of four quarters, with the home team's 14-point fourth quarter putting the game out of reach. The victory saw the spread covered by the home team, while the final score surpassed the over-under at 62.5 points.