UConn defeated Buffalo 20-17 in a tightly contested Week 5 matchup featuring 14 lead changes and defensive intensity throughout. The Huskies scored first in the second quarter when Joe Fagnano connected with Skyler Bell for a touchdown pass, while Buffalo answered with a 63-yard rushing touchdown from Lamar Sperling. The second half remained competitive, with UConn extending its lead in the third quarter before Buffalo mounted a fourth-quarter comeback, highlighted by a touchdown pass from G. Gray to A. Henderson that cut the deficit to three points.

UConn's defense generated the game's most impactful play, recording a six-point EPA swing against Buffalo in the second quarter. Joe Fagnano led the Huskies with 155 passing yards and 64 rushing yards, while Victor Snow paced Buffalo's receivers with 68 yards. The game fell under the 51-point over-under, with the final margin matching the pregame spread at 3 points, resulting in a spread push. Neither team gained separation, with the lead changing hands repeatedly in a defensive showcase.